Fig. 5.

5TGM1 cell engraftment is associated with bone lesions and osteopenia in chronic intermittent hypoxia (CIH)-exposed mice. A and C: representative three-dimensional bone surface mesh image used for bone lesion counting in normoxia controls (A) and paralyzed CIH-exposed mice (C). B and D: representative bone thickness heat map images of tail and spine in a normoxia control (B) and paralyzed CIH mouse (D), used for bone thickness analysis. E: paralyzed CIH-exposed mice have more lesions per bone, relative to normoxia control. F: CIH-exposed group had decreased bone thickness compared with normoxia control. *P < 0.05.G: hematoxylin and eosin-stained slide showing normal bone marrow of a normoxia control mouse. H: hematoxylin and eosin-stained slide of the bone marrow of a paralyzed CIH-exposed mouse showing malignant plasma cells infiltrating the bone cavity.