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. 2019 Jun 3;116(25):12500–12505. doi: 10.1073/pnas.1820131116

Fig. 5.

Fig. 5.

LB-100, an inhibitor of PP2A activity, restores changes in excitatory synapses and motor deficits in Ube3am−/p+ mice. (A) Representative mEPSC traces (Left) and average waveforms (Right) from acute brain slices of motor cortex of P30 mice, conditions as indicated. (B and C) Quantification of mEPSC frequencies and amplitudes. n represents the number of cells: WT, n = 12; Ube3am−/p+, n = 9; Ube3am−/p++LB-100, n = 9; WT+LB-100, n = 13; one-way ANOVA with Tukey’s posttest. (D) Schematic of experimental design. i.p., intraperitoneal. (E) Wire suspension test. n = 7 mice per condition; one-way ANOVA with Tukey’s posttest. (F) Rotarod test. n = 8 mice per condition; two-way ANOVA with Bonferroni posttest. Error bars indicate mean ± SEM; ***P < 0.001, **P < 0.01, *P < 0.05, n.s., not significant.