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. 2017 Jul 20;29(5):486–495. doi: 10.1080/09537104.2017.1336210

Figure 2.

Figure 2.

Effects of podoplanin crosslinking on LEC migration. A) LEC settled onto a Transwell filter were treated with antibody against podoplanin or a nonspecific IgG, with or without a crosslinking secondary antibody, with or without treatment with VEGF-C (300 ng/ml). The percentage of the LEC which had transmigrated after 24 h was analyzed. Data are mean ± SEM from three experiments. ANOVA showed significant effects of VEGF-C and of antibody treatment (p < 0.01 in each case). **=p < 0.01 compared to no antibodies by Dunnett’s test, for VEGF-C-treated LEC. B) LEC settled onto a Transwell filter were treated with VEGF-C (300 ng/ml), FGFb (10 ng/ml) or EGF (20 ng/ml), with or without antibodies to induce crosslinking of podoplanin. The percentage of the LEC which had transmigrated after 24h was analyzed. Data are mean ± SEM from at least three experiments. **=p < 0.01 by paired t test.