Fig. 5.

Muscle morphology after serial sarcomere addition as a result of casting in normal and satellite cell-depleted muscle (see text for details). Hematoxylin- and eosin-stained sections of muscle with depleted satellite cell number (tamoxifen treated) (A) and vehicle control (B) after immobilization and stretch show smaller fibers and hypercellular extracellular matrix after satellite cell depletion. C: muscle fiber area in cross sections from tamoxifen-treated mice, vehicle control-treated mice, and uncasted mice. D: %muscle tissue from histological cross sections in tamoxifen-treated mice, vehicle control-treated mice, and uncasted mice. Data represent means ± SE, n = 4–5/group. (Data replotted from Ref. 28.)