Fig. 5.

The six genes correlated with change in insulin sensitivity that also increased more than twofold in the High Susceptibility Group. BBOX1-AS1(A) USP6 (B), FLYWCH1P1 (C), IGFN1 (D), APOB (E), and PLXNA4 (F). Statistical design included CLIX-IR category + CLIX-IR:nested + CLIX-IR:time. Fold changes were determined using maximum-likelihood estimates of the log2 fold change. An adjusted P value of P < 0.05 was required for a gene to be considered significantly altered. Low Susceptibility Group: n = 14; High Susceptibility Group: n = 12.