Table 1.
Subject characteristics
| Low Susceptibility | High Susceptibility | ||||
|---|---|---|---|---|---|
| Age, yr | 52 (SD 23) (5/9) | 53 (SD 23) (4/8) | |||
| Sample Size (male/female) | 14 (8/6) | 12 (5/7) | ANOVA P Values | ||
| Height, cm | 172 (SD 8) | 175 (SD 5) | |||
| Pre | Post | Pre | Post | Bed Rest | Low vs. High | Interaction | |
|---|---|---|---|---|---|---|---|
| Body mass, kg† | 74 (SD 14) | 73 (SD 14) | 71 (SD 9) | 69 (SD 8) | <0.001 | 0.435 | 0.263 |
| BMI† | 25.03 (SD 3.8) | 24.78 (SD 3.7) | 23.04 (SD 2.2) | 22.65 (SD 2.1) | <0.001 | 0.103 | 0.337 |
| Fat mass, kg | 23 (SD 7) | 23 (SD 7) | 22 (SD 6) | 22 (SD 5) | 0.238 | 0.569 | 0.803 |
| Whole body lean mass, kg† | 48 (SD 10) | 47 (SD 9) | 46 (SD 7) | 45 (SD 6) | <0.001 | 0.508 | 0.136 |
| Insulin sensitivity (CLIX-IR)† | 5.51 (SD 2.0) | 4.64 (SD 1.7) | 7.02 (SD 2.7) | 3.65 (SD 1.5) | <0.001 | 0.729 | <0.001 |
| HOMA-IR | 1.54 (SD 0.8) | 1.50 (SD 0.8) | 0.97 (SD 0.3) | 1.18 (SD 0.6) | 0.223 | 0.118 | 0.121 |
| Matsuda Index† | 7.78 (SD 4.1) | 7.59 (SD 6.0) | 12.4 (SD 4.5)* | 7.75 (SD 2.9) | 0.002 | 0.166 | 0.003 |
| Fasting glucose, mg/dl† | 92 (SD 6) | 94 (SD 6) | 91 (SD 10) | 96 (SD 14) | 0.020 | 0.895 | 0.309 |
| Fasting insulin, µU/ml‡ | 6.68 (SD 3.2) | 6.35 (SD 3.3) | 3.99 (SD 1.9) | 4.88 (SD 1.7) | 0.435 | 0.046 | 0.091 |
| 120 min glucose, mg/dl† | 116 (SD 23) | 122 (SD 35) | 108 (SD 21) | 134 (SD 55) | 0.048 | 0.839 | 0.176 |
| 120 min insulin, µU/ml† | 58.4 (SD 70) | 63.4 (SD 35) | 21.7 (SD 19) | 32.0 (SD 18) | 0.041 | 0.120 | 0.468 |
| AUC glucose, g·dl−1·min−1† | 15244 (SD 2185) | 16154 (SD 2859) | 14228 (SD 2827) | 17493 (SD 4756) | 0.001 | 0.889 | 0.048 |
| AUC insulin, µU·ml−1·min−1† | 5914 (SD 4749) | 6846 (SD 2859) | 2749 (SD 934.9) | 4896 (SD 1968) | <0.001 | 0.089 | 0.049 |
Values are expressed as means (SD). BMI, body mass index; CLIX-IR, Clamp-Like Index; HOMA-IR, homeostatic model assessment of insulin resistance.
*
Different from Low Susceptibility with interaction (Sidak’s multiple-comparison test, P < 0.05).
†
Bed rest effect;
‡
Group difference.