Table 2:
Characteristics of the propensity matched cohort
| Non-glycopeptide N=10585 |
Vancomycin N=10585 |
Standardized Difference |
|
|---|---|---|---|
| Mean age (SD), years | 66.1 (10.7) | 66.1 (10.7) | 0.0054 |
| Gender, n (%) Males | 10239 (96.7) | 10233 (96.7) | −0.0032 |
| Race, n (%) | |||
| Whites | 7927 (74.9) | 7918 (74.8) | 0 |
| African Americans | 2198 (20.8) | 2208 (20.9) | |
| Other | 460 (4.4) | 459 (4.3) | |
| Mean eGFR (SD), mL/min/1.73m2 | 70.94 (32.2) | 71.17 (28) | 0.0079 |
| SBP (SD), mmHg | 137.3 (22.2) | 137.3 (22.3) | −0.0003 |
| DBP (SD), mmHg | 74.65 (13.5) | 74.65 (13.4) | 0.0049 |
| BMI (SD), kg/m2 | 27.6 (7.8) | 28.37 (7.9) | 0.0017 |
| Comorbidities, n (%) | |||
| MI | 1154 (10.9) | 1159 (10.9) | 0.0015 |
| CHF | 2822 (26.7) | 2861 (27) | 0.0083 |
| PVD | 3406 (32.2) | 3379 (31.9) | −0.0055 |
| CVA | 2521 (23.8) | 2573 (24.3) | 0.0115 |
| Dementia | 388 (3.7) | 384 (3.6) | −0.002 |
| Chronic Pulmonary Disease | 5280 (49.9) | 5278 (49.9) | −0.0004 |
| Liver Disease | 1681 (15.9) | 1671 (15.8) | −0.0026 |
| Diabetes | 5473 (51.7) | 5502 (52) | 0.0055 |
| Cancer | 3235 (30.6) | 3214 (30.4) | −0.0043 |
| Hypertension | 8779 (82.9) | 8789 (83) | 0.0025 |
| Ischemic Heart Disease | 4471 (42.2) | 4525 (42.7) | 0.0103 |
| CCI (IQR) | 3(2–5) | 3(2–5) | −0.0006 |
| Medications, n (%) | |||
| Analgesics | 5694 (53.8) | 5739 (54.2) | 0.0085 |
| Other Antibiotics | 556 (5.3) | 583 (5.5) | 0.0113 |
| Cardiovascular drugs use | 3137 (29.6) | 3186 (30.1) | 0.0101 |
| Contrast dye | 239 (2.3) | 246 (2.3) | 0.0044 |
| Diuretics | 4282 (40.5) | 4341 (41) | 0.0113 |
| Proton pump inhibitors | 5603 (52.9) | 5622 (53.1) | 0.0036 |
| Dobutamine/Norepinephrine | 861 (8.1) | 864 (8.2) | 0.0 01 |
| No of other antibiotics | |||
| 0 | 10029 (94.7) | 10002 (94.5) | 0.0113 |
| 1 | 491 (4.6) | 515 (4.9) | |
| 2 | 59 (0.6) | 60 (0.6) | |
| 3 | 6 (0.1) | 8 (0.1) |
Data were summarized using proportions, means ± SD, or medians (interquartile range (IQR)) as appropriate
Abbreviations: SD: Standard Deviation; AKI: Acute Kidney Injury; CHF: Congestive Heart Failure; PVD: Peripheral Vascular Disease; CVA: Cerebrovascular Accident; MI: Myocardial Infarction; eGFR: Estimated Glomerular Filtration Rate; BMI: Body Mass Index; CCI: Charlson Comorbidity Index; SBP: Systolic Blood Pressure; DBP: Diastolic Blood Pressure SOFA: Sequential Organ Failure Assessment, ALT: Alanine aminotransferase; AST: aspartate aminotransferase