FIGURE 9:

Role or Rap1 in the protective effect of HTV-LTV switch on LPS-induced lung injury. LPS administration (intratracheal) of Rap1−/− mice and matched wild-type controls was performed 18 h before exposure to different regimens of mechanical ventilation. The experiment was terminated after 4 h of mechanical ventilation. (A) BAL cell count measurements. (B) BAL protein content measurements. Data are expressed as mean ± SD of four independent experiments; *, p < 0.05. (C) Evans blue dye (30 ml/kg, i/v) was injected 30 min before termination of the experiment. Photographs depict lung vascular permeability assessed by Evans blue accumulation in the lung tissue.