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. 2019 Feb 28;24(6):615–627. doi: 10.1177/2472555219830087

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© 2019 Society for Laboratory Automation and Screening

This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 3. — 3D cultures of PDX material. PDX material from different tumors can be cultured in 3D hydrogels to form complex microtissues that can be used for compound screening in a preclinically relevant context. Actin cytoskeleton visualized with rhodamine-phalloidin. PDX tumor material provided by Charles River Labs (Freiburg, Germany). Annotations refer to tumor type and PDX model number; BX = bladder; MAX = mammary; GX = gastric; PAX = pancreatic; LX = lung. 3D cultures and images generated by OcellO B.V.