Table 1. Cost-effectiveness of a point-of-care multiplex PCR diagnostic platform in the management of hospitalised patients with suspected infections.
| Units | Unit cost | Total cost | Notes | |
|---|---|---|---|---|
| One-step multiplex PCR device | 0.2 | $35,000 | $7,000 | Assume 5-year useful life |
| Server and peripheral equipment | 0.2 | $5,000 | $1,000 | |
| Laptop | 0.2 | $1,200 | $240 | |
| Laboratory technician | 12 | $1,000 | $12,000 | |
| Total annual capital and labour costs | $20,240 a | |||
| Samples per annum | 1825 b | Assume 5 samples/day 15 | ||
| Capital and labour cost per sample | $11 c | a/b | ||
| Multiplex panel (one per sample) | 1 | $155 | $155 d | |
| Other consumables | 1 | $5 | $5 e | |
| Total cost per sample | $171 | c+d+e | ||
| Three scenarios for CFR without PCR | 5%, 7%, 10% | |||
| Three scenarios for CFR with PCR | 4%, 5%, 7% | |||
| DALYs per death | 50 | WHO age-adjusted life
expectancy, based on a median age of 21 in hospitalised inpatients from a fever study in rural Laos 16 |
||
| Cost/DALY in three comparative scenarios | $342, $171, $114 | |||
DALY, disability adjusted life year.