Deng 2010.

Methods	Randomised clinical trial, China Parallel group design
Participants	68 participants diagnosed with moderate or severe chronic hepatitis B according to Chinese guidelines 2000 (CMA 2001). Serum TBIL > 34.2 μmol/L. Male:female: 55:13 Mean age: 40.2 years (experimental group), 47.5 years (control group) Exclusion criteria: with obvious heart, brain, kidney, or nervous system diseases; extrahepatic obstructive jaundice verified by colour ultrasound or CT tests.
Interventions	Experimental intervention: matrine glucose solution, 250 mL, once daily, intravenous infusion, 1 month (n = 36) Control intervention: yin zhi huang injection, 30 mL, with 5% glucose solution 250 mL, once daily, intravenous infusion, 1 month (n = 32) Cointervention: diammonium glycyrrhizinate injection, 150 mg, once a day, intravenous injection; and reduced glutathione, 250 mL, once daily, intravenous infusion, 1 month Post‐treatment follow‐up: no follow‐up
Outcomes	Clinical symptoms; liver (function) tests (ALT, AST, TBIL)
Notes	Study dates: May 2007 to May 2008 Funding information: author did not provide any information on clinical study support or sponsorship. Notes: we contacted the authors on 29 June 2018 by telephone and received no reply.
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	Used random number table to generate random sequence
Allocation concealment (selection bias)	Unclear risk	Not reported
Blinding of participants and personnel (performance bias) All outcomes	Unclear risk	Not reported
Blinding of outcome assessment (detection bias) All outcomes	Unclear risk	Not reported
Incomplete outcome data (attrition bias) All outcomes	Low risk	The number of participants included in the analysis was equal to the number of participants randomised; no missing data.
Selective reporting (reporting bias)	High risk	We could not obtain the protocol, and author did not report any data on the primary outcomes.
Other bias	Unclear risk	Paper only had 1 author, and author did not mention any acknowledgements. If the trial was conducted by a single person, there would be potential risks of bias in every step.