Table 1.
Univariate Proportional Hazards Models for Prediction of DFS and OS
| Factor | DFS |
OS |
Comparison | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| HR | 95% CI | P | HR | 95% CI | P | ||||||
| ErbB-2 by IHC (dichotomous) | 1.19 | 0.96 to 1.46 | .11 | 1.31 | 1.04 to 1.64 | .021* | Positive v negative | ||||
| ≥ 50% v < 50% | |||||||||||
| ERBB-2 by FISH (dichotomous) | 1.32 | 0.95 to 1.83 | .093 | 1.51 | 1.07 to 2.14 | .019* | Positive v negative | ||||
| < 2.0 v ≥ 2.0 | |||||||||||
| PN2A (dichotomous) | 1.33 | 1.03 to 1.73 | .032* | 1.30 | 0.97 to 1.73 | 0.078 | Positive v negative | ||||
| > 0% v 0% | |||||||||||
| ErbB-2/PN2A† | .09 | .14 | |||||||||
| ErbB-2 = 0% | 1.00 | 1.00 | |||||||||
| ErbB-2 low/PN2A− | 0.99 | 0.78 to 1.24 | 0.97 | 0.75 to 1.26 | |||||||
| ErbB-2 low/PN2A+ | 1.83 | 1.08 to 3.10 | 1.47 | 0.80 to 2.70 | |||||||
| ErbB-2 high/PN2A− | 1.16 | 0.89 to 1.53 | 1.31 | 0.97 to 1.75 | |||||||
| ErbB2 high/PN2A+ | 1.26 | 0.93 to 1.72 | 1.32 | 0.94 to 1.85 | |||||||
NOTE. For ErbB-2 by IHC, n = 910; for ERBB-2 by FISH, n = 500.
Abbreviations: DFS, disease-free survival; OS, overall survival; HR, hazard ratio; IHC, immunohistochemistry; FISH, fluorescence in situ hybridization.
*
Statistically significant at P < .05.
†
Compare each following row to first row (ie, ErbB-2 = 0%).