Table 3.

Associations between the polymorphisms of high-mobility group box 1 (HMGB1) and the epidermal growth factor receptor hotspot mutations in lung adenocarcinoma patients.

Variable	Wild type	L858R		Exon 19 in-frame deletion
	(N=111) (%)	(N=79) (%)	AOR (95% CI)	(N=81) (%)	AOR (95% CI)
rs1412125
TT	59 (53.2%)	39 (49.4%)	1.00	46 (56.8%)	1.00
TC	43 (38.7%)	34 (43.0%)	1.033 (0.522~2.044)	28 (34.6%)	0.640 (0.328~1.250)
CC	9 (8.1%)	6 (7.6%)	1.109 (0.319~3.852)	7 (8.6%)	0.870 (0.290~2.608)
TC+CC	52 (46.8%)	40 (50.6%)	1.045 (0.545~2.003)	35 (43.2%)	0.683 (0.366~1.272)
rs2249825
CC	74 (66.7%)	55 (69.6%)	1.00	65 (80.2%)	1.00
CG	34 (30.6%)	21 (26.6%)	0.767 (0.370~1.591)	15 (18.5%)	0.473 (0.228~0.979)*,a
GG	3 (2.7%)	3 (3.8%)	1.234 (0.196~7.757)	1 (1.2%)	0.349 (0.032~3.811)
CG+GG	37 (33.3%)	24 (30.4%)	0.804 (0.397~1.626)	16 (19.8%)	0.463 (0.227~0.941)*,b
rs1045411
CC	62 (55.9%)	44 (55.7%)	1.00	52 (64.2%)	1.00
CT	41 (36.9%)	29 (36.7%)	0.913 (0.457~1.823)	26 (32.1%)	0.766 (0.402~1.459)
TT	8 (7.2%)	6 (7.6%)	0.963 (0.275~3.370)	3 (3.7%)	0.448 (0.106~1.884)
CT+TT	49 (44.1%)	35 (44.3%)	0.921 (0.477~1.779)	29 (35.8%)	0.715 (0.385~1.330)
rs1360485
TT	60 (54.1%)	42 (53.2%)	1.00	46 (56.8%)	1.00
TC	40 (36.0%)	31 (39.2%)	0.989 (0.493~1.986)	31 (38.3%)	1.042 (0.549~1.977)
CC	11 (9.9%)	6 (7.6%)	0.843 (0.252~2.820)	4 (4.9%)	0.498 (0.140~1.769)
TC+CC	51 (45.9%)	37 (46.8%)	0.961 (0.496~1.864)	35 (43.2%)	0.929 (0.504~1.714)

The adjusted odds ratios (AORs) with 95% confidence intervals (CIs) were estimated by multiple logistic regression models after controlling for age and gender.

Note: Bold text indicates a significant association with a p value of <0.05.

Abbreviations: SNP, single-nucleotide polymorphism.

^a p value=0.044; ^b p value=0.033.