Table 3.
Clinicopathologic characteristics of 36 patients with genital malformations who developed carcinomas
| Variables | Category | N | % |
|---|---|---|---|
| Parity (n=30) | 0 | 10 | 33.3 |
| 1 | 8 | 26.7 | |
| ≥2 | 12 | 40.0 | |
| Symptoms (n=31) | Postcoital VB | 4 | 12.9 |
| Vaginal discharge | 3 | 9.7 | |
| Intermenstrual VB | 17 | 54.8 | |
| Periodic hematuria | 1 | 3.2 | |
| Abnormal Pap smear | 3 | 9.7 | |
| Postmenopausal VB | 3 | 9.7 | |
| Sites of carcinoma | Cervix | 22 | 61.1 |
| Vagina | 10 | 27.8 | |
| Cervix and vagina | 4 | 11.1 | |
| *FIGO stage of cervical carcinoma (n=25) | Ⅰ | 13 | 52.0 |
| Ⅱ | 9 | 36.0 | |
| Ⅲ | 1 | 4.0 | |
| Ⅳ | 2 | 8.0 | |
| FIGO stage of vaginal carcinoma (n=10) | Ⅰ | 6 | 60.0 |
| Ⅱ | 3 | 30.0 | |
| Ⅲ | 1 | 10.0 | |
| Pathology of cervix and vagina | Adenocarcinoma | 25 | 69.4 |
| SCC | 10 | 27.8 | |
| ASC | 1 | 2.8 | |
| Urinary tract malformation | URA | 21 | 58.3 |
| Others | 2 | 5.6 | |
| No malformation | 13 | 36.1 | |
| Genital tract malformation | HWWS | 8 | 22.2 |
| Uterus didelphys | 17 | 47.2 | |
| Others | 11 | 30.6 | |
| Sites of carcinoma in patients with 2 cervices | One cervix | 9 | 45.0 |
| (n=20) | Two cervices | 8 | 40.0 |
| Vagina (no cervix) | 3 | 15.0 |
*1 carcinoma in situ was not included
Abbreviations: ASC, adenosquamous carcinoma; HWWS, Herlyn-Werner-Wunderlich syndrome; PUMCH, Peking Union Medical College Hospital; SCC, squamous-cell carcinoma; URA, unilateral renal agenesis; VB, vaginal bleeding