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Biogenesis and regulations of circRNAs. Three modes of circRNA biogenesis are shown in the ring. (a) Flanking intron pairing, which contains ALU repeats, drives the formation of backsplicing. (b) Lariat-driven circularization shapes a lariat. The lariat is spliced. 5'-GU-rich and 3'-C-rich regions assist intron circularization and shape ciRNAs. (c) RBP is involved in the circularization. Based on this, the regulation of circRNA is shown in A, B and C.
