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. Author manuscript; available in PMC: 2019 Nov 1.
Published in final edited form as: Methods. 2018 Aug 2;150:3–10. doi: 10.1016/j.ymeth.2018.07.012

Fig 3. The base editor system for non-nuclease editing of the zebrafish genome.

Fig 3.

The third generation base editor (BE3) catalyzes G:C to an A:T deamination with the fused APOBEC1 nucleobase deaminase. Base excision repair is prevented by the fused uracil glycosylase inhibitor (UGI). The formation of the AT transition is further biased by introducing a nick on the non-edited strand to drive mismatch repair and subsequent resolution to the A:T basepair106,109.