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. 2019 Jun 17;9:504. doi: 10.3389/fonc.2019.00504

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Copyright © 2019 Wen, Guo, Zhang, Li, Jiang, Di, Ma, Feng, Zhang and Shou.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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NETs and F3 in tissues are independent prognostic factors in ccRCC patients. (A) Kaplan-Meier plots of the overall survival of ccRCC patients (n = 533) from the TCGA database stratified by the NET score quartile (left, p = 0.000566) and median NET score (right, p = 0.0359). The bottom list shows the adjusted HR for NETs by clinical stage (HR = 16.18). (B) Kaplan-Meier plots of the overall survival of ccRCC patients (n = 533) from the TCGA database stratified by the TF expression quartile (left, p = 0.49 × 10⁻⁵) and median TF expression value (right, p = 0.0134). The bottom list shows the adjusted HR for TF expression by clinical stage (HR = 1.12). (C) The NET score and TF expression value were positively correlated.