Table 3.

Prediction models for disability

Prediction model disability (EDSS score) at 6‐year FU
Adjusted R 2  = 0.559	Standardized β	P‐value
EDSS score (BL–2 years)	0.465	<0.001
PPMS at BL	0.214	0.004
Early whole‐brain atrophy rate (PBVC)	−0.143	0.026

Prediction model disability (EDSS score) at 12‐year FU
Adjusted R 2  = 0.375	Standardized β	P‐value
EDSS score (BL–2 years)	0.443	<0.001
T1‐hypointense lesion volume at BL	0.245	0.008

Prediction models for physical disability 6 and 12 years after BL. Both prediction models are corrected for baseline EDSS and the model for year 6 was also corrected for disease‐modifying treatment use during FU. Standardized β and corresponding P‐value are given per included variable. BL, baseline; EDSS, Expanded Disability Status Scale; FU, follow‐up; PBVC, percentage brain volume change per year; PPMS, primary progressive multiple sclerosis.