Table 4.

Prediction models for cognitive decline

Prediction model cognition at 6‐year FU
Adjusted R 2  = 0.255	Standardized β	P‐value
High versus low level of education	0.503	<0.001
Middle versus low level of education	0.364	0.004
Male sex	−0.213	0.013
PPMS at BL	−0.201	0.019
Early whole‐brain atrophy rate (PBVC)	0.181	0.039

Prediction model cognition at 12‐year FU
Adjusted R 2  = 0.141	Standardized β	P‐value
Male sex	−0.256	0.019
High versus low level of education	0.242	0.026
T1‐hypointense lesion volume at BL	−0.220	0.041

Prediction models for cognitive decline 6 and 12 years after BL. Standardized β and corresponding P‐value are given per included variable.

BL, baseline; FU, follow‐up; PBVC, percentage brain volume change per year; PPMS, primary progressive multiple sclerosis.