Table 3.
Meta‐analyses of risk estimates for specific cancers among children conceived by fertility treatment
| Outcome | No. of studies | RR (95% CI) | p value | Test of heterogeneity | Test of publication bias | ||
|---|---|---|---|---|---|---|---|
| I 2 (%) | p value | t | p value | ||||
| CNS tumours | 8 | 1.01 (0.76, 1.32) | 0.96 | 41 | 0.11 | 1.342 | 0.228 |
| Neuroblastoma | 7 | 1.20 (0.86, 1.67) | 0.27 | 10 | 0.35 | 0.080 | 0.938 |
| Leukemia | 13 | 1.31 (1.09, 1.57) | < 0.001 | 25 | 0.19 | 0.551 | 0.592 |
| Lymphoma | 6 | 1.09 (0.74, 1.61) | 0.65 | 0 | 0.57 | 0.169 | 0.874 |
| Retinoblastoma | 8 | 1.98 (0.85, 4.63) | 0.12 | 68 | < 0.001 | 0.795 | 0.457 |
| Hepatic tumours | 7 | 2.26 (1.32, 3.85) | < 0.001 | 35 | 0.16 | 1.485 | 0.198 |
| Renal tumours | 6 | 1.25 (0.68, 2.30) | 0.47 | 60 | 0.03 | 0.229 | 0.830 |
| Bone tumors and extraosseous sarcomas | 5 | 1.27 (0.73, 2.19) | 0.40 | 66 | 0.02 | 0.571 | 0.608 |
| Germ cell tumours | 5 | 0.81 (0.37, 1.80) | 0.61 | 19 | 0.29 | 0.643 | 0.566 |
Abbreviations: CI, confidence interval; CNS, central nervous system; RR, risk ratio.