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. 2018 Dec 27;46(3):177–185. doi: 10.1111/1346-8138.14749

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© 2018 The Authors. The Journal of Dermatology published by John Wiley & Sons Australia, Ltd on behalf of Japanese Dermatological Association.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

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There are three significant amino acid residue phosphorylation sites: S800, S502 and S704. T704 and S800 contribute to protein kinase C (PKC)‐induced hypersensitivity to heat. S502 and S800 contribute to PKC‐induced hypersensitivity to capsaicin. S800 contributes to PKC‐induced hypersensitivity to acid. These phosphorylation sites may serve as the targets for the development of antipruritic drugs in the future. TRPV1, transient receptor potential channel vanilloid 1.