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A variety of exogenous and endogenous activators or sensitizers of transient receptor potential channel ankyrin transmembrane protein 1 (TRPA1) have been identified, such as mustard oil compounds (allyl isothiocyanate, AITC), garlic compounds (allicin), cinnamon compounds (cinnamaldehyde) and environment (acrolein). These agonists directly modify C619, C639 and C663 cystein residue targets.
