Table 1.

Itch‐related inflammatory mediators and corresponding diseases with chronic cutaneous itch

Inflammatory mediators	Corresponding diseases
IL‐31	AD,23, 26, 28, 29, 30, 31, 32 CTCL,26, 29, 30 chronic urticaria,29, 30 PN,29, 30, 31 CSU23, 32
IL‐4 and IL‐13	AD12, 33, 34, 35, 36
NGF	CTCL,41 PN,30, 31 AD,25 psoriasis42
Histamine	AD,29 eczema,6, 7 urticaria,6, 7
TSLP	AD10
IL‐2 and IFN‐γ	Uremic pruritus,50 AD10

Many itch‐related inflammatory mediators such as IL‐2, IL‐4, IL‐13, IL‐31, NGF, histamine, TSLP and IFN‐γ are related to a variety of diseases which could cause cutaneous chronic itch. AD, atopic dermatitis; CSU, chronic spontaneous urticaria; CTCL, cutaneous T‐cell lymphoma; IFN, interferon; IL, interleukin; NGF, nerve growth factor; PN, prurigo nodularis; TSLP, thymic stromal lymphopoietin.