Table 1.
Baseline demographics and clinical characteristics of patients with SE treated with perampanel
| All patients (n = 52) | Perampanel responders (n = 19) | Perampanel non‐responders (n = 33) | |
|---|---|---|---|
| Baseline demographics | |||
| Mean age (SD), y | 60.5 (19.7) | 55.6 (21.0) | 62.2 (18.7) |
| Female, n (%) | 28 (53.8) | 10 (52.6) | 18 (54.5) |
| Clinical characteristics | |||
| mRS score before admission | |||
| Median (range) | 3 (0‐5) | 3 (0‐5) | 3 (0‐4) |
| STESS score at admission | |||
| Median (range) | 3 (0‐6) | 3 (0‐6) | 3 (0‐6) |
| Pre‐existing epilepsy, n (%) | 26 (50.0) | 10 (52.6) | 16 (48.5) |
| SE etiology, n (%) | |||
| Structural | 45 (86.5) | 15 (78.9) | 30 (90.9) |
| Hypoxic | 5 (9.6) | 2 (10.5) | 3 (9.1) |
| Other | 2 (3.8) | 2 (10.5) | 0 (0.0) |
| SE semiology, n (%) | |||
| GTCSE | 20 (38.5) | 5 (26.3) | 15 (45.5) |
| NCSE | 13 (25.0) | 5 (26.3) | 8 (24.2) |
| Other | 19 (36.5) | 9 (47.4) | 10 (30.3) |
| SE refractoriness, n (%) | |||
| SE | 1 (1.9) | 1 (5.3) | 0 (0.0) |
| RSE | 28 (53.8) | 12 (63.2) | 16 (48.5) |
| SRSE | 23 (44.2) | 6 (31.6) | 17 (51.5) |
| Number of failed AEDs before perampanel | |||
| Median (range) | 5 (0‐13) | 5 (0‐13) | 6 (3‐10) |
AED, antiepileptic drug; GTCSE, generalized tonic‐clonic status epilepticus; mRS, modified Rankin Scale; NCSE, non‐convulsive status epilepticus; RSE, refractory status epilepticus; SD, standard deviation; SE, status epilepticus; SRSE, super‐refractory status epilepticus; STESS, status epilepticus severity score.