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MUC1 modulates TNF‐α‐induced 16HBE cells necroptosis. MUC1‐CT binds RIPK1 when it is released from an epithelial cell in response to TNF‐α. Then, it affects the phosphorylation of RIPK1 at Ser166. Upon activation, RIPK1 recruits RIPK3 to necrosome to initiate necroptosis. 16HBE: human bronchial epithelial; RIPK1: receptor‐interacting protein kinase‐1; RIPK3: receptor‐interacting protein kinase‐3; TNF‐α: tumor necrosis factor‐α [Color figure can be viewed at wileyonlinelibrary.com]
