Table 1.
Outcome | Covariates (cut point) | Univariate analysis | Multivariate analysis | ||
---|---|---|---|---|---|
HR (95%CI) | p | HR (95% CI) | p | ||
TTFT | IL‐6 a (>9.35vs.≤9.35) | 2.910 (1.461–5.796) | 0.002 | 3.597 (1.27–10.12) | 0.015 |
Stage (B/C vs. A) | 3.770 (1.865–7.619) | <0.0001 | 0.751 (0.215–2.620) | 0.654 | |
17p11q (+vs.−) | 2.072 (1.033–4.155) | 0.040 | 1.711 (0.508–5.763) | 0.386 | |
ZAP‐70 (+vs.−) | 3.033 (1.270–7.245) | 0.012 | 2.652 (0.843–8.349) | 0.095 | |
CD38 (+vs.−) | 1.832 (0.908–3.693) | 0.091 | – | – | |
PFS | IL‐6 a (>9.35vs.≤9.35) | 2.910 (1.345–6.298) | 0.007 | 3.581 (1.017–12.61) | 0.047 |
Stage (B/C vs. A) | 4.245 (1.933–9.324) | <0.0001 | 1.246 (0.282–5.499) | 0.771 | |
17p11q (+vs.−) | 1.992 (0.908–4.371) | 0.086 | 1.571 (0.343–7.201) | 0.561 | |
ZAP‐70 (+vs.−) | 2.854 (1.009–8.069) | 0.048 | 2.006 (0.528–7.614) | 0.307 | |
CD38 (+vs. −) | 2.088 (0.957–4.558) | 0.065 | – | – |
Note. Covariates that were included in the multivariate analysis were first selected using the Enter and then the backward/forward stepwise.
CI: confidence interval; HR: hazard ratio; PFS: progression‐free survival; TTFT: shorter time to first time treatment.
Categorical cut‐off points were defined by the X‐tile software, N = 71.