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. 2019 Jan 8;234(8):13994–14006. doi: 10.1002/jcp.28086

Table 1.

Uni‐ and multi‐variate analysis of categorical covariates of TTFT and PFS

Outcome Covariates (cut point) Univariate analysis Multivariate analysis
HR (95%CI) p HR (95% CI) p
TTFT IL‐6 a (>9.35vs.≤9.35) 2.910 (1.461–5.796) 0.002 3.597 (1.27–10.12) 0.015
Stage (B/C vs. A) 3.770 (1.865–7.619) <0.0001 0.751 (0.215–2.620) 0.654
17p11q (+vs.−) 2.072 (1.033–4.155) 0.040 1.711 (0.508–5.763) 0.386
ZAP‐70 (+vs.−) 3.033 (1.270–7.245) 0.012 2.652 (0.843–8.349) 0.095
CD38 (+vs.−) 1.832 (0.908–3.693) 0.091
PFS IL‐6 a (>9.35vs.≤9.35) 2.910 (1.345–6.298) 0.007 3.581 (1.017–12.61) 0.047
Stage (B/C vs. A) 4.245 (1.933–9.324) <0.0001 1.246 (0.282–5.499) 0.771
17p11q (+vs.−) 1.992 (0.908–4.371) 0.086 1.571 (0.343–7.201) 0.561
ZAP‐70 (+vs.−) 2.854 (1.009–8.069) 0.048 2.006 (0.528–7.614) 0.307
CD38 (+vs. −) 2.088 (0.957–4.558) 0.065

Note. Covariates that were included in the multivariate analysis were first selected using the Enter and then the backward/forward stepwise.

CI: confidence interval; HR: hazard ratio; PFS: progression‐free survival; TTFT: shorter time to first time treatment.

a

Categorical cut‐off points were defined by the X‐tile software, N = 71.