Table 3.
Final Model Parameter Estimates
| Name | Estimate | Standard Error (RSE%)a | 95%CIb |
|---|---|---|---|
| Grade 3 or 4 alanine aminotransferase elevation | |||
| Intercept for non‐Asian (θ1) | –3.91 | 0.252 (6.44) | –4.54, –3.52 |
| Asian on intercept (θ3) | 1.53 | 0.311 (20.4) | 0.865, 2.20 |
| Slope of ASV (ng/mL, θ4) | 0.0017 | 0.00065 (38.3) | 0.00034, 0.00305 |
| BWT (kg) effect on intercept for non‐Asian(θ2) | –0.0475 | 0.0148 (31.2) | –0.0829, –0.0163 |
| Grade 3 or 4 total bilirubin elevation | |||
| Intercept for non‐Asian (θ1) | –6.79 | 0.658 (9.69) | –9.19, –6.1 |
| Slope of ASV (ng/mL, θ2), (ng/mL)−1 | 0.00321 | 0.000898 (28) | 0.00168, 0.00545 |
| Asian on intercept (θ3) | 2.01 | 0.624 (31) | 0.892, 3.81 |
| Fibrosis Grade 4 on intercept (θ4) | 1.64 | 0.563 (34.3) | 0.485, 2.97 |
ASV, asunaprevir; BWT, baseline body weight; CI, confidence interval; RSE, relative standard error.
a
RSE% is the relative standard error (standard error as a percentage of estimate).
b
Confidence interval values are taken from bootstrap calculations (1000 run, sampled stratified by study).