Table 1.
Baseline characteristics of study participants according to Week 24 HbA1c responder groups
| Good responders | Poor responders | |||
|---|---|---|---|---|
| HbA1c <7.0% (<53 mmol/mol) | All HbA1c ≥7.0% (≥53 mmol/mol) | Sub‐optimal HbA1c 7.0%‐8.0% (53‐64 mmol/mol) | Minimal HbA1c >8.0% (>64 mmol/mol) | |
| n = 1584 | n = 1831 | n = 1262 | n = 569 | |
| Age (median, range), y | 57.9 (26.7‐82.4) | 57.8 (19.6‐86.2) | 58.1 (19.6‐84.7) | 57.1 (21.3‐86.2) |
| Men, n (%) | 901 (56.9) | 916 (50.0) | 641 (50.8) | 275 (48.3) |
| Body weight, kg | 87.6 (17.6) | 84.8 (18.7) | 85.6 (18.3) | 83.1 (19.5) |
| BMI, kg/m2 | 30.8 (5.0) | 30.3 (5.4) | 30.5 (5.4) | 29.9 (5.4) |
| Diabetes duration (median, range), y | 7.0 (0.0‐43) | 8.0 (0.4‐50.0) | 8.0 (0.4‐45.0) | 9.0 (0.6‐50.0) |
| Gla‐100 starting dose, U/d | 12.8 (5.1) | 13.9 (6.6) | 13.3 (5.6) | 15.3 (8.2) |
| Gla‐100 starting dose, U/kg | 0.15 (0.06) | 0.17 (0.09) | 0.16 (0.07) | 0.19 (0.11) |
| HbA1c, % | 8.41 (0.95) | 9.01 (1.01) | 8.82 (0.97) | 9.44 (0.98) |
| HbA1c, mmol/mol | 68.4 (10.4) | 75.0 (11.0) | 72.9 (10.6) | 79.7 (10.7) |
| n = 1567 | n = 1816 | n = 1251 | n = 565 | |
| FPG, mmol/L | 10.2 (2.7) | 11.1 (3.2) | 10.8 (3.0) | 11.8 (3.4) |
| FPG, mg/dL | 184.1 (49.2) | 199.7 (57.3) | 193.9 (54.2) | 213.2 (61.8) |
| n = 1232 | n = 1421 | n = 968 | n = 453 | |
| 2‐h SMPG overalla, mmol/L | 11.7 (3.1) | 13.3 (3.5) | 12.7 (3.3) | 14.4 (3.8) |
| 2‐h SMPG overalla, mg/dL | 210.5 (55.3) | 238.9 (63.9) | 229.6 (59.0) | 258.6 (69.4) |
| n = 883 | n = 1216 | n = 817 | n = 399 | |
| Fasting C‐peptide, nmol/L | 1.16 (0.57) | 1.14 (0.64) | 1.13 (0.57) | 1.16 (0.77) |
Abbreviations: BMI, body mass index; FPG, fasting plasma glucose; Gla‐100, glargine 100 U/mL; HbA1c, glycated haemoglobin A1c; SMPG, self‐monitored plasma glucose.
Values are given as mean (standard deviation) or as stated. Group numbers vary with missing values.
a
From 7‐point SMPG profiles: average 2 h post‐breakfast, lunch and evening meal.