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Two examples to show the prediction performance of the human PBPK model on plasma concentrations. Observed (red dots for parent drugs, blue dots for the generated metabolites) and predicted (arithmetic mean as solid lines with 95% confidence interval) plasma concentration time profiles were obtained after oral administration of clozapine (A) and risperidone (B) according to the studies of Hägg et al41 and Cánovas et al,59 respectively.
