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Model for host cell invasion by T. cruzi metacyclic trypomastigote (MT) mediated by gp82 binding to LAMP‐2 protein. MT gp82 binds to host cell LAMP‐2, present at low levels at the plasma membrane, and triggers lysosome scattering to the cell periphery. This increases the availability of LAMP‐2 as receptor for gp82 and further promotes MT internalisation within a vacuole resulting from the fusion of lysosomes with the plasma membrane
