Table 1.

Demographic and Baseline Characteristics

	Degree of Renal Impairment
Characteristic	Normal (n = 6)	Mild (n = 6)	Moderate (n = 6)	Severe (n = 6)
Age (y)a	63.2 ± 6.79	62.2 ± 8.52	68.2 ± 10.5	59.7 ± 8.19
	(53–71)	(48–70)	(47–75)	(47–70)
Weight (kg)a	81.2 ± 17.0	87.9 ± 21.9	81.6 ± 11.2	84.5 ± 16.9
	(54.5–102)	(55.6–120)	(66.0–95.2)	(53.4–105)
Height (cm)a	169 ± 9.95	170 ± 9.32	169 ± 5.04	165 ± 5.84
	(150–177)	(158–182)	(163–178)	(154–170)
BMI (kg/m2)a	28.3 ± 3.34	30.2 ± 6.53	28.7 ± 3.96	31.1 ± 6.61
	(24.3–33.2)	(22.3–37.5)	(24.0–33.7)	(20.0–37.9)
Sex
Male	4 (67%)	4 (67%)	4 (67%)	4 (67%)
Female	2 (33%)	2 (33%)	2 (33%)	2 (33%)
Race
White	5 (83%)	3 (50%)	5 (83%)	6 (100%)
Black	1 (17%)	3 (50%)	0	0
Asian	0	0	1 (17%)	0
eGFR	110 ± 15.6	61.3 ± 7.94	43.5 ± 8.17	21.2 ± 5.12
(mL/min/1.73 m2)a	(94–133)	(50–70)	(31–52)	(15–30)
CLcr	119 ± 23	74.9 ± 22.3	52.6 ± 13.3	32 ± 9.15
(mL/min)a	(84.8–141)	(53.4–116)	(39.2–76.8)	(16.2–41.1)

BMI, body mass index; CL_cr, creatinine clearance; eGFR, estimated glomerular filtration rate.

^aMean ± standard deviation.