Figure 3.

The effects of PIP on OSCC migration and invasion in vitro. (a) The view of wound‐healing migration assay; the average rate of SCC15 and SCC25 cells migration at 12 and 24 hr after control, PIP vector or siRNA‐PIP transfection. All data were shown as mean ± SD. *p < 0.05, **p < 0.01. (b) The results of the transwell assay of SCC15 and SCC25 cells at 24 hr after control, PIP vector or siRNA‐PIP transfection; relative ratios of migrated and invasive cells per field are shown. All data were shown as mean ± SD. *p < 0.05, **p < 0.01. OSCC: oral squamous cell carcinoma; PIP: prolactin‐inducible protein; SD: standard deviation; siRNA: small interfering RNA [Color figure can be viewed at wileyonlinelibrary.com]