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. 2019 Jan 11;144(12):3160–3173. doi: 10.1002/ijc.32059

Figure 4.

Figure 4

Th2‐like polarized response and ECM remodeling correlated with FI. Expression of genes involved in Th2‐like response (a), linked to Th2‐like response (b) or tissue remodeling (c) showed high correlation with FI, Pearson R = 0.83, 0.78 and 0.78, respectively (p < 0.0001). (d) Dose dependent massive infiltration of inflammatory cells, collagen deposition and distorted lung parenchyma at 24‐week post IR assessed by H&E and Masson's trichrome staining (20× magnification). FI correlated well with the relative macrophage and fibrosis scores (Pearson R = 0.97 and 0.99, respectively, both p < 0.05). [Color figure can be viewed at wileyonlinelibrary.com]