. 2019 Jan 29;85(2):194–203. doi: 10.1002/ana.25396

Table 2.

Effects of Obesity, Cardiovascular Risk Factors, and Inflammatory Markers on Global Markers of WMH Distribution, and Load, According to Linear Regression Models Controlled for Age and Sex

		dWMH/pvWMH			Total WMH Volume
	n	βs; β, [95% CI]	p	sr²	βs; β, [95% CI]	p	sr²
BMI	1,825	0.056; 0.013 [0.002–0.023]	0.018	0.0030	0.053; 0.013 [0.004–0.023]	0.005	0.0024
WHR	1,825	0.097; 1.01 [0.32–1.70]	0.004	0.0044	0.11; 1.32 [0.71–1.9]	<10 ^–4	0.0054
Diastolic BP	1,825	0.039; 0.004 [–0.001 to 0.008]	0.095	0.0015	0.11; 0.012 [0.008–0.016]	<10 ^–7	0.0122
Systolic BP	1,825	0.023; 0.001 [–0.001 to 0.004]	0.35	0.0005	0.14; 0.009 [0.006–0.011]	<10 ^–11	0.0179
HbA1c	1,825	0.026; 0.043 [–0.032 to 0.12]	0.26	0.0007	0.04; 0.071 [0.004–0.14]	0.038	0.0012
Smoking	1,825	–0.037; –0.078 [–0.17 to 0.02]	0.12	0.0005	0.061; 0.087 [0.035–0.14]	0.001	0.0033
CRP	1,825	0.052; 0.052 [0.006–0.098]	0.026	0.0026	0.043; 0.048 [0.008–0.089]	0.019	0.0015
IL6	1,372	0.074; 0.11 [0.029–0.18]	0.007	0.0051	0.046; 0.078 [0.008–0.15]	0.029	0.0017
		Deep WMH Volume			Periventricular WMH Volume
BMI	1,825	0.065; 0.012 [0.004–0.019]	0.003	0.0038	0.036; 0.007 [4 × 10^–4 to 0.014]	0.065	0.0012
WHR	1,825	0.12; 1.03 [0.53–1.53]	<10 ^–4	0.0069	0.092; 0.77 [0.32–1.23]	<10 ^–3	0.0038
BMI^a	1,825	0.035; 0.006 [0.001–0.12]	0.017	0.0007	–0.006; –0.001 [–0.006 to 0.004]	0.63	<10^–4
WHR^a	1,825	0.80; 0.42 [0.76–0.83]	0.018	0.0038	0.01; 0.086 [–0.23 to 0.4]	0.60	0.0027

Statistical significant results are marked in bold.

Controlled additionally for periventricular WMH (in models with deep WMH as dependent variable) or for deep WMH (in models with periventricular WMH as dependent variable).

β = beta coefficient; βs = standardized coefficient; sr² = semipartial correlation coefficient; BMI = body mass index; BP = blood pressure; CI = confidence interval; CRP = high‐sensitive C‐reactive protein; IL6 = interleukin‐6; WHR = waist‐to‐hip ratio.