Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Two-step enzymatic reaction of glutathione synthesis. The first step is the coupling of L-glutamate and cysteine to produce γ-glutamylcysteine under the catalysis of glutamate-cysteine ligase (GCL). The second step is the coupling of γ-glutamylcysteine to glycine catalyzing by glutathione synthetase (GS). Each reaction consumes one ATP molecule. Glutathione exists in the forms of reduced GSH and oxidized GSSG.
