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The role of cellular GSH in apoptosis and necroptosis. GSH depletion through nutrition starvation or GSH synthesis inhibition or conjugation with GSH or GSH efflux or GSH degradation induces ROS generation which results in the occurrence of proapoptotic signals, such as the disruption of MMP, increased bax, decreased bcl2, cytochrome c release, and caspase activation. Excess ROS accumulation induces necroptosis.
