Table 2.
Agents for inhibition of communication between CAFs and GC cells.
| Author | Year | Agents | Origin | Cell lines | Target molecules | Tools | Outcomes | Reference |
|---|---|---|---|---|---|---|---|---|
| Yashiro M et al. | 2003 | Tranilast | Chemical | OCUM-2D | Matrix metalloproteinse-2 Transforming growth factor-beta 1 |
Invasion assay | Invasiveness | [51] |
|
| ||||||||
| Onoyama M et al. | 2013 | Nilotinib with Everolimus |
Chemical | TMK-1 MKN-1 KKLS |
PDGF-R tyrosine kinase and Mammalian target of rapamycin |
Xenograft | Tumor growth Angiogenesis Metastasis Stromal reaction |
[52] |
|
| ||||||||
| Hara M et al. | 2016 | Itraconazole | Chemical | HT-29 (colon) MKN-28 MKN-45 |
Mitogen-activated protein kinase Protein S6 |
Flow cytometry Angiogenesis assay Xenograft |
Angiogenesis Tumor growth |
[53] |
|
| ||||||||
| Izumi D et al. | 2016 | AF-310-NA AMD3100 PF-573,228 |
Antibody Chemical Chemical |
AGS KATOIII |
CXCL12 CXCR4 Focal adhesion kinase |
Real-time imaging Invasion assay |
Migration Invasiveness |
[42] |
|
| ||||||||
| Jin H et al. | 2017 | 7rh | Chemical | MKN-45 MKN-74 |
Discoidin domain receptor 1 | Spheroid culture Xenograft |
Tumorigenesis | [54] |
|
| ||||||||
| Pang T et al. | 2017 | Fiber-modified hexon-chimeric oncolytic adenovirus | Adenovirus | MKN-45 | Fibroblast activation protein (for CAF-specific infection) |
Cell viability assay Xenograft |
Tumor growth | [55] |
|
| ||||||||
| Wang Z et al. | 2017 | Triptonide | Natural products (Tripterygium wilfordii) | BGC-823 | microRNA-149 ↑ microRNA-301a ↓ |
Colony formation assay Wound healing assay Invasion assay |
Tumorigenesis Migration Invasiveness |
[56] |
|
| ||||||||
| Wang ZF et al. | 2017 | Astragaloside IV | Natural products (Astragali Radix) | BGC-823 | microRNA-214 ↑ microRNA-301a ↓ |
Proliferation assay Wound healing assay Invasion assay |
Proliferation Migration Invasiveness |
[57] |
|
| ||||||||
| Ding X et al. | 2018 | LY294002 U0126 |
Chemical | AKT ERK 1/2 |
Angiogenesis assay | Angiogenesis | [58] | |
|
| ||||||||
| Dong R et al. | 2018 | Polyphyllin I | Chemical | MKN-45 | Fibroblast activation protein alpha Hepatocyte growth factor |
Proliferation assay Xenograft |
Proliferation Tumor growth |
[59] |
|
| ||||||||
| Karakasheva TA et al. | 2018 | Tocilizumab | Antibody | ESCC EAC |
IL-6 receptor alpha | 3D culture 3D organotypic culture Xenograft |
Tumorigenesis | [60] |
|
| ||||||||
| Wang ZF et al. | 2018 | Paeoniflorin | Natural products (Radix Paeoniae Rubra) |
AGS | microRNA-149 Interleukin 6 |
Wound healing assay Invasion assay |
Migration Invasiveness |
[61] |
|
| ||||||||
| Chen G et al. | 2019 | Metformin | Chemical | Calmodulin-like protein 3 | Proliferation assay | Tumor promotion | [62] | |