Figure 5.

Functional effects of the administration of ADSCs in emphysema model mice. (a) A pulmonary function test was performed in mice in the following four groups: control, administered 50 μl PBS intratracheally; PPE+/ADSCs−, administered PPE intratracheally; PPE−/ADSCs+, administered 50 μl PBS intratracheally and injected with ADSCs intravenously; and PPE+/ADSCs+, administered PPE intratracheally and injected with ADSCs intravenously. Lung compliance indicated as C chord and vital capacity were measured by the lung function analysis system (n = 4 in the control group, n = 5 in the PPE+/ADSC− group, n = 6 in the PPE−/ADSC+ group, and n = 5 in the PPE+/ADSC+ group on each day). ^∗ P < 0.01. (b) Representative hyperpolarized ¹²⁹Xe magnetic resonance imaging (MRI). A representative map of the gas exchange efficiency (f _D) and the ventilation efficiency (s) is shown. The values of f _D and ra were measured (n = 5 in the control group, n = 5 in the PPE+/ADSC− group, n = 3 in the PPE−/ADSC+ group, and n = 5 in the PPE+/ADSC+ group). ^∗ P < 0.05.