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Irisin prevented STZ-induced working memory deterioration in DM mice. (a) STZ treatment caused significantly decreased spontaneous alternation of DM mice in the Y maze test. Irisin could prevent the decrease of the working memory performance of DM mice. (b) Neither STZ nor irisin could change the total arm entries of these mice. All data are expressed as means ± SEM. n = 10. ∗p < 0.05 vs. STZ (-) and irisin (-); #p < 0.05 vs. STZ (+) and irisin (-).
