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Irisin reduced the level of IL-6 and IL-1β in the CSF of DM mice exposed to STZ. (a) STZ increased the level of IL-1β in the CSF of DM mice, but irisin treatment could reduce the upregulation of IL-1β. (b) STZ increased the level of IL-6 in the CSF of DM mice, and irisin treatment could reduce the upregulation of IL-6. All data are expressed as means ± SEM. n = 6. ∗p < 0.05 vs. Cont; #p < 0.05 vs. STZ.
