Figure 6.

Irisin reduced the activation of p38, STAT3, and NFκB proteins in the brain hippocampal tissues of DM mice. (a) Representative western blot photograph and statistical results of p-p38 and total p38 in hippocampal tissues of all groups. (b) Representative western blot photograph and statistical results of p-STAT3 and total STAT3 in hippocampal tissues of all groups. (c) NFκB/DNA binding activity was determined by EMSA. All data are expressed as means ± SEM. n = 5. ^∗p < 0.05 vs. Cont; ^#p < 0.05 vs. STZ.