Table 3.
TLR4, RANKL, and OPG genotype frequency distributions between patients with periodontitis and control after stratification according to gender.
| Genotype (n and %) | Female | Male | P | OR (95%CI) | |||
|---|---|---|---|---|---|---|---|
| Patients | Controls | Patients | Controls | ||||
| All subjects ∗ | |||||||
| TLR4 A896G rs4986790 | N = 223 | N = 156 | |||||
| A/A | 79 (35.4) | 110 (49.3) | Ref. | 71 (45.5) | 66 (42.3) | 0.01 | 2.86 (1.02-8.00) |
| A/G | 18 (8.1) | 16 (7.2) | 13 (8.4) | 6 (3.8) | |||
|
| |||||||
| Nonsmokers ∗∗ | |||||||
| TLR4 C1196T rs4986791 | N = 159 | N = 85 | |||||
| C/C | 47 (29.6) | 90 (56.6) | Ref. | 38 (44.7) | 39 (45.9) | 0.02 | 1.85 (1.05-3.28) |
| C/T | 11 (6.9) | 11 (6.9) | 4 (4.7) | 4 (4.7) | |||
| RANKL rs2277438 | N = 144 | N = 99 | |||||
| A/A | 37 (25.7) | 57 (39.6) | Ref. | 33 (33.3) | 26 (26.3) | 0.03 | 1.96 (1.01-3.78) |
| G/A | 18 (12.5) | 28 (19.4) | 19 (19.2) | 20 (20.2) | |||
| G/G | 2 (1.4) | 2 (1.4) | 0 | 1 (1.0) | |||
| Patients | Controls | ||||||
| OPG C163T rs3102735 | N = 111 | N = 145 | |||||
| T/C | Female | 14 (12.6) | 29 (20.0) | Ref. | |||
| Male | 14 (12.6) | 10 (6.9) | 0.04 | 2.9 (1.03-8.14) | |||
∗Multivariate analyses adjusted by age and smoking habits. ∗∗Multivariate analyses adjusted by age. Only significant results are shown. Ref.: genotype used as reference; n: number of individuals with the allele or genotype; %: allele and genotype frequencies ×100; N: sample size; P: P value; OR: odds ratio (adjusted values); CI: confidence interval.