Figure 2.

Cognitive performance of SAM. (a) Escape latency in SAMR1 and SAMP8 mice at 4, 6, and 8 months of age, during seven consecutive days of Morris water maze test training. Cognitive performance of SAMR1 and SAMP8 mice at 4, 6, and 8 months of age, during the probe trial session of the Morris water maze test; (b) number of target crossings; (c) entries into the target quadrant; (d) time spent within the target quadrant. Data are expressed as mean ± S.E.M. obtained from 8 animals. Differences among groups were evaluated by two-way analysis of variance followed by post hoc analysis with the Fisher LSD test or a one-way analysis of variance followed by post hoc analysis with the Student-Newman-Keuls test where appropriate. ^∗P < 0.05 between the indicated subgroups.