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. Author manuscript; available in PMC: 2020 Jun 15.
Published in final edited form as: Biol Psychiatry. 2019 Mar 11;85(12):1011–1020. doi: 10.1016/j.biopsych.2019.02.021

Figure 1.

Figure 1

(A) Timeline depicting the MSEW paradigm. (B) MSEW male mice from cohort 1 displayed increased anxiety-like behavior in the EPM, making significantly lower percent entries in to the open and higher entries into closed arms. (C) MSEW mice spent significantly more time in the closed arms of the EPM. (D) MSEW male mice from cohort 2 displayed increased anxiety-like behavior in the EPM, making significantly lower percent entries into the open arms and higher percent entries into closed arms. (E) MSEW mice from cohort 2 did not show any differences in percent time spent in the open or close arms. *p<0.05