Skip to main content
. Author manuscript; available in PMC: 2020 Jul 1.
Published in final edited form as: Anesthesiology. 2019 Jul;131(1):132–147. doi: 10.1097/ALN.0000000000002730

Figure 1:

Figure 1:

Time course depicting the mean ± SD of the hind paw thermal escape latency (sec) versus time in rats prepared with chronic intrathecal catheters connected to osmotic pumps delivering 0.5 μL/hr for 14 days and loaded to deliver: A) Saline (vehicle, 0.5 μL/hr); B) Morphine (33 nmol/hr); C) DMT-DALDA (10 pmol/hr) or D) PZM21 (28 nmol/hr). E) Area Under the curve (AUC) (mean ± SD) was calculated from baseline to day 7 for the 4 treatment groups. For the time course curves, one-way repeated measures ANOVA were performed with Dunnett’s multiple comparison tests versus day 0 (immediately prior to implantation). For the AUC data, analysis was by a one-way non-repeated ANOVA with a Dunnett’s multiple comparison tests versus saline infusion: * p<0.05; **p<0.01; ***p<0.001; ****p<0.0001.