Table 1.
Genes Containing the Gene Ontology:Cell Component Term “Extracellular” That are Upregulated in ad-Primed ADipose Progenitor Cells (PADS) Compared to PADS
| Gene symbol | Biweight Average signal (Log2) | |||||
|---|---|---|---|---|---|---|
| pre-PADS | PADS | Fold change (linear) | ANOVA p-value | FDR p-value | Description | |
| COL12A1 | 15.62 | 16.63 | 2.02 | 0.034278 | 0.738561 | Collagen, type XII, alpha 1 |
| COL3A1 | 14.76 | 15.83 | 2.1 | 0.014497 | 0.706983 | Collagen, type III, alpha 1 |
| ADIPOQ | 6.02 | 14.15 | 278.53 | 0.001938 | 0.63372 | Adiponectin |
| PPP2R1B | 9.85 | 12.13 | 4.83 | 0.012173 | 0.706983 | Protein phosphatase 2, regulatory subunit A, beta |
| ERV3-1 | 9.04 | 11.89 | 7.22 | 0.001606 | 0.63372 | Endogenous retrovirus group 3, member 1; zinc finger protein 117 |
| HSPG2 | 10.6 | 11.75 | 2.22 | 0.011174 | 0.702326 | Heparan sulfate proteoglycan 2 |
| ACACA | 8.75 | 11.6 | 7.2 | 0.035299 | 0.738561 | Acetyl-CoA carboxylase alpha |
| CAT | 9.87 | 11.22 | 2.56 | 0.01749 | 0.717727 | Catalase |
| LPL | 4.61 | 11.06 | 87.66 | 0.008961 | 0.697682 | Lipoprotein lipase |
| ECHDC1 | 9.19 | 11.01 | 3.52 | 0.030393 | 0.730714 | Ethylmalonyl-CoA decarboxylase 1 |
| HP | 5 | 10.98 | 63.29 | 0.007908 | 0.694757 | Haptoglobin |
| C7 | 7.59 | 10.97 | 10.39 | 0.023862 | 0.725644 | Complement component 7 |
| RBP4 | 7.18 | 10.59 | 10.6 | 0.019018 | 0.720701 | Retinol binding protein 4, plasma |
| FZD4 | 8.85 | 10.56 | 3.27 | 0.035148 | 0.738561 | Frizzled class receptor 4 |
| OLFM2 | 8.37 | 10.53 | 4.47 | 0.003836 | 0.640504 | Olfactomedin 2 |
| COL4A1 | 8.43 | 10.19 | 3.37 | 0.049268 | 0.765581 | Collagen, type IV, alpha 1 |
| PLA2G2A | 7.93 | 10.06 | 4.38 | 0.011995 | 0.70568 | Phospholipase A2, group IIA (platelets, synovial fluid) |
| CHI3L2 | 6.32 | 9.95 | 12.39 | 0.000282 | 0.453651 | Chitinase 3-like 2 |
| MCAM | 5.94 | 9.87 | 15.28 | 0.012533 | 0.706983 | Melanoma cell adhesion molecule |
| GHR | 6.74 | 9.76 | 8.12 | 0.014529 | 0.706983 | Growth hormone receptor |
| LBP | 5.63 | 9.7 | 16.82 | 0.011861 | 0.70411 | Lipopolysaccharide binding protein |
| GPD1 | 5.6 | 9.42 | 14.16 | 0.009315 | 0.69817 | Glycerol-3-phosphate dehydrogenase 1 |
| PRKAR2B | 6.2 | 9.41 | 9.23 | 0.007145 | 0.68923 | Protein kinase, cAMP-dependent, regulatory, type II, beta |
| CHL1 | 7.79 | 9.02 | 2.35 | 0.042315 | 0.752979 | Cell adhesion molecule L1 like |
| COL5A1 | 7.58 | 8.62 | 2.06 | 0.045381 | 0.756446 | Collagen, type V, alpha 1 |
| FABP5 | 5.73 | 8.46 | 6.6 | 0.011525 | 0.702953 | Fatty acid binding protein 5 (psoriasis associated) |
| ADIRF | 6.54 | 8.29 | 3.36 | 0.020917 | 0.724127 | Adipogenesis regulatory factor |
| EFNA5 | 6.89 | 8.14 | 2.37 | 0.016816 | 0.717167 | Ephrin-A5 |
| PRL | 5.67 | 7.91 | 4.72 | 0.001102 | 0.625574 | Prolactin |
| APOE | 6.45 | 7.71 | 2.4 | 0.038401 | 0.742836 | Apolipoprotein E |
| ITIH5 | 6.35 | 7.67 | 2.51 | 0.005753 | 0.666918 | Inter-alpha-trypsin inhibitor heavy chain family, member 5 |
| HPR | 5.36 | 7.32 | 3.9 | 0.012947 | 0.706983 | Haptoglobin-related protein; haptoglobin |
| SERPINB2 | 5.66 | 7.13 | 2.78 | 0.043889 | 0.752979 | Serpin peptidase inhibitor, clade B (ovalbumin), member 2 |
| MAOB | 5.48 | 6.65 | 2.24 | 0.0157 | 0.711636 | Monoamine oxidase B |
| ADAMTS9 | 4.89 | 6.57 | 3.23 | 0.003176 | 0.63372 | ADAM metallopeptidase with thrombospondin type 1 motif 9 |
| TRHDE | 4.77 | 6.51 | 3.36 | 0.014351 | 0.706983 | Thyrotropin-releasing hormone-degrading enzyme |
| CKMT1B | 5.17 | 6.22 | 2.07 | 0.042988 | 0.752979 | Creatine kinase, mitochondrial 1B; creatine kinase, mitochondrial 1A |
| PPP1R1A | 5.19 | 6.21 | 2.03 | 0.015221 | 0.711636 | Protein phosphatase 1, regulatory (inhibitor) subunit 1A |
| CKMT1A | 4.42 | 5.53 | 2.15 | 0.049139 | 0.765232 | Creatine kinase, mitochondrial 1A; creatine kinase, mitochondrial 1B |
The signals are means from five independent arrays, and values are sorted based on intensity of signal in ad-PADS.
ANOVA, analysis of variance; FDR, false discovery rate; PADS, primed ADipose progenitor cells.