Table 2. Population pharmacokinetic parameters for danofloxacin in 3-week old vs. 6-month old calves with respiratory disease.

Population Values—Final NLME Model
Parameter	Units	Estimate	Stderr	CV%
TMAX	h	2.2	0.9	60.8
CMAX	μg/mL	3.0	1.4	79.4
θV	L/kg	2.9	0.26	9.1
θV2	L/kg	1.22	0.24	19.7
Cl	L/kg/h	0.26	0.017	6.9
Cl2	L/kg/h	0.03	0.0045	13.5
T½*	h	29.5	2.2	40.7

Population values from NLME model and median and range of PK parameters from compartmental analysis after single S.C. injection of 8 mg/kg danofloxacin in 3-week-old vs. 6-month-old calves with induced respiratory disease with P. multocida.

*Indicates significantly different by t-test (P < 0.01).