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. Author manuscript; available in PMC: 2020 Jun 4.
Published in final edited form as: J Am Coll Cardiol. 2019 Jun 4;73(21):2691–2700. doi: 10.1016/j.jacc.2019.02.071

Table 3.

Rates of total number of 30-day heart failure re-hospitalizations across level of kidney function among participants with chronic kidney disease

Model 1 Model 2 Model 3
Number of
participants
Number of HF
hospitalizations
Total number of
30-day HF
rehospitalizations
Crude rate,
per 100 pys
(95% CIs)
Overall 3791 1706 238 0.8 (0.6, 1.0)
eGFR stage
  eGFR ≥ 45 1714 437 53 0.4 (0.2, 0.5) 1.0 (Ref.) 1.0 (Ref.) 1.0 (Ref.)
  eGFR 30-44 1379 766 111 1.1 (0.7, 1.4) 2.5 (1.5, 4.1) 2.2 (1.3, 3.6) 1.9 (1.2, 3.1)
  eGFR < 30 698 503 74 1.5 (0.8, 2.2) 3.4 (1.9, 6.2) 3.0 (1.6, 5.6) 2.6 (1.4, 4.7)
Albuminuria
  uACR < 30 1629 383 43 0.3 (0.2, 0.4) 1.0 (Ref.) 1.0 (Ref.) 1.0 (Ref.)
  uACR 30 - < 300 1001 510 80 1.0 (0.6, 1.5) 3.2 (1.8, 5.5) 2.7 (1.5, 4.7) 2.7 (1.5, 4.8)
  uACR ≥ 300 1161 813 115 1.4 (0.9, 1.9) 4.6 (2.7, 7.7) 3.6 (1.8, 7.1) 3.6 (1.8, 7.3)
CKD category
  eGFR ≥ 45, uACR < 300 1401 253 29 0.2 (0.1, 0.4) 1.0 (Ref.) 1.0 (Ref.) 1.0 (Ref.)
  eGFR < 45, uACR < 300 1229 640 94 1.0 (0.7, 1.4) 3.4 (1.9, 6.1) 3.2 (1.8, 5.7) 2.8 (1.6, 4.9)
  eGFR ≥ 45, uACR > 300 313 184 24 1.0 (0.4, 1.6) 4.5 (2.1, 9.7) 3.6 (1.6, 8.2) 3.8 (1.6, 8.7)
  eGFR < 45, uACR > 300 848 629 91 1.5 (0.9, 2.2) 5.5 (3.0, 10.2) 4.2 (2.0, 8.8) 3.8 (1.8, 8.1)

All rate ratios with p-value<0.05

eGFR= estimated glomerular filtration rate; uACR= urine albumin-to-creatinine-ratio

Model 1: age, sex, and race/ethnicity

Model 2: model 1 + diabetes, history of cardiovascular disease, use of lipid-lowering medications, smoking, systolic blood pressure, and body mass index

Model 3: model 2 + use of diuretics, angiotensin-converting-enzyme inhibitors/aldosterone receptor blockers, β-blockers