Table 3.
Model 1 | Model 2 | Model 3 | |||||
---|---|---|---|---|---|---|---|
Number of participants |
Number of HF hospitalizations |
Total number of 30-day HF rehospitalizations |
Crude rate, per 100 pys (95% CIs) |
||||
Overall | 3791 | 1706 | 238 | 0.8 (0.6, 1.0) | |||
eGFR stage | |||||||
eGFR ≥ 45 | 1714 | 437 | 53 | 0.4 (0.2, 0.5) | 1.0 (Ref.) | 1.0 (Ref.) | 1.0 (Ref.) |
eGFR 30-44 | 1379 | 766 | 111 | 1.1 (0.7, 1.4) | 2.5 (1.5, 4.1) | 2.2 (1.3, 3.6) | 1.9 (1.2, 3.1) |
eGFR < 30 | 698 | 503 | 74 | 1.5 (0.8, 2.2) | 3.4 (1.9, 6.2) | 3.0 (1.6, 5.6) | 2.6 (1.4, 4.7) |
Albuminuria | |||||||
uACR < 30 | 1629 | 383 | 43 | 0.3 (0.2, 0.4) | 1.0 (Ref.) | 1.0 (Ref.) | 1.0 (Ref.) |
uACR 30 - < 300 | 1001 | 510 | 80 | 1.0 (0.6, 1.5) | 3.2 (1.8, 5.5) | 2.7 (1.5, 4.7) | 2.7 (1.5, 4.8) |
uACR ≥ 300 | 1161 | 813 | 115 | 1.4 (0.9, 1.9) | 4.6 (2.7, 7.7) | 3.6 (1.8, 7.1) | 3.6 (1.8, 7.3) |
CKD category | |||||||
eGFR ≥ 45, uACR < 300 | 1401 | 253 | 29 | 0.2 (0.1, 0.4) | 1.0 (Ref.) | 1.0 (Ref.) | 1.0 (Ref.) |
eGFR < 45, uACR < 300 | 1229 | 640 | 94 | 1.0 (0.7, 1.4) | 3.4 (1.9, 6.1) | 3.2 (1.8, 5.7) | 2.8 (1.6, 4.9) |
eGFR ≥ 45, uACR > 300 | 313 | 184 | 24 | 1.0 (0.4, 1.6) | 4.5 (2.1, 9.7) | 3.6 (1.6, 8.2) | 3.8 (1.6, 8.7) |
eGFR < 45, uACR > 300 | 848 | 629 | 91 | 1.5 (0.9, 2.2) | 5.5 (3.0, 10.2) | 4.2 (2.0, 8.8) | 3.8 (1.8, 8.1) |
All rate ratios with p-value<0.05
eGFR= estimated glomerular filtration rate; uACR= urine albumin-to-creatinine-ratio
Model 1: age, sex, and race/ethnicity
Model 2: model 1 + diabetes, history of cardiovascular disease, use of lipid-lowering medications, smoking, systolic blood pressure, and body mass index
Model 3: model 2 + use of diuretics, angiotensin-converting-enzyme inhibitors/aldosterone receptor blockers, β-blockers