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. Author manuscript; available in PMC: 2019 Jun 24.
Published in final edited form as: J Med Chem. 2019 Apr 18;62(9):4350–4369. doi: 10.1021/acs.jmedchem.8b01772

Figure 6. 8j and 19f inhibit LPA induced CTGF gene expression.

Figure 6

Primary dermal fibroblasts from healthy donors were pre-treated with varying concentrations of 8j (CCG-58150) and 19f (CCG-232964) for (A) 48 h or (B) 72 h and stimulated with 1 µM LPA for 1 h. CTGF mRNA levels were measured by qPCR. Results are expressed as the mean ± SEM. *p<0.05, **p<0.01 vs DMSO control using One-way ANOVA; n>3.