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. Author manuscript; available in PMC: 2019 Jun 24.
Published in final edited form as: J Med Chem. 2019 Apr 18;62(9):4350–4369. doi: 10.1021/acs.jmedchem.8b01772

Figure 7. 5-Aryl-1,3,4-oxadiazol-2-ylthioalkanoic Acids Prevent Bleomycin-Induced Dermal Fibrosis.

Figure 7

Mice treated with inhibitors displayed significantly reduced skin thickness and collagen content as compared to vehicle control. (A) Masson’s trichrome stained skin sections from PBS (left panel), Bleomycin + Vehicle control (middle panel), and Bleomycin +10 mg/kg 8j (right panel). N=10 per group (B) Quantification of A, by measuring the distance between the subcutaneous fat and the epidermis. *, p<0.05 by using One-way ANOVA (C) Masson’s trichrome stained skin sections for PBS (left panel), Bleomycin+Vehicle (middle left panel), Bleomycin +3 mg/kg 19f (middle right panel) or Bleomcyin +10 mg/kg 19f (right panel). N=7 per group (D) Quantification of C. ****, p<0.0001, using One-way ANOVA. (E) Quantification of collagen content by hydroxyproline measurement. ****, p<0.0001, using One-way ANOVA.